Congenital Anomaly produced by lithium therapy is
**Core Concept**
Lithium is a mood stabilizer used in the treatment of bipolar disorder. However, its use during pregnancy can lead to congenital anomalies due to its teratogenic effects. The underlying mechanism involves the inhibition of glycogen synthase and the disruption of cell membrane function.
**Why the Correct Answer is Right**
Lithium can cause congenital anomalies, particularly cardiac malformations such as Ebstein's anomaly. This is thought to be due to the inhibition of glycogen synthase, which disrupts the normal development of the heart. The exact mechanism is not fully understood, but it is believed to involve the disruption of cell membrane function and the inhibition of protein synthesis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify a known congenital anomaly associated with lithium therapy.
**Option B:** This option is incorrect because it is not a known congenital anomaly associated with lithium therapy.
**Option C:** This option is incorrect because it is not a known congenital anomaly associated with lithium therapy.
**Clinical Pearl / High-Yield Fact**
Lithium can cause cardiac malformations, particularly Ebstein's anomaly, which is a congenital heart defect characterized by an abnormal development of the tricuspid valve and right ventricle. This is an important consideration for pregnant women taking lithium.
**Correct Answer: C. Ebstein's anomaly**