Congenital 17-hydroxylase deficiency leads to hypeension due to accumulation of?
Correct Answer: Deoxycoicosterone
Description: * Two forms of adrenal hyperplasia (ie, 11-hydroxylase and 17-hydroxylase deficiency) result in hypeension due to the accumulation of supraphysiologic concentrations of deoxycoicosterone. * This weak mineralocoicoid has little consequence at physiologic concentrations but causes sodium retention and hypeension at the supraphysiologic concentrations that occur in these conditions.
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