All the above four options is answer Ref Robbins 7/e p657; 9/e p664-665 severe falciparum malaria: The incidence and progression of coagulation abnormalities were studied in 52 patients with acute falciparum malaria. The patients were prospectively divided into 3 groups; severe (parasitaemia greater than or equal to 5% or vital organ dysfunction), 12 patients; moderate (parasitaemia 1%- less than 5% without complications), 16 patients; and mild (parasitaemia less than 1%), 24 patients. No case died or developed clinical evidence of disseminated intravascular coagulation. Conventional indices of coagulation (prothrombin time, paial thromboplastin time, fibrinogen, fibrin degradation products) were usually within the normal range but reduced plasma concentrations of antithrombin III (AT-III) levels were noted in all groups, and the incidence was significantly higher in patients with severe and moderate malaria (83% and 81%) compared with the mild group (37%; P less than 0.005). Depletion of AT-III was associated with thrombocytopenia, acute promyelocytic leukemia: Acute promyelocytic leukemia (APL) is a is a unique subtype of acute leukemiacharacterized by abnormal proliferation of promyelocytes, life-threatening coagulopathy, and the chromosome translocation t(15;17)(q22;q11-12). heparin overdose: Heparin is an anticoagulant, meaning it inhibits the formation of blood clots in the body. In heparin overdose, the body is unable to deploy its natural defenses against hemorrhage (excessive bleeding), and life-threatening blood loss can occur quickly. Excessive bleeding from an open wound is unlikely to go unnoticed, but internal bleeding can be sneakier. All patients receiving heparin should be monitored closely for the signs and symptoms of internal bleeding due to delayed clotting action abruption placentae: Placental abruption can cause life-threatening problems for both mother and baby. For the mother, placental abruption can lead to: Shock due to blood loss Blood clotting problems (disseminated intravascular coagulation)