Concentric hypertrophy of heart is seen in –
**Core Concept**
Concentric hypertrophy of the heart refers to a type of cardiac remodeling characterized by an increase in the thickness of the left ventricular wall due to an increase in the number of myocytes and the extracellular matrix. This adaptation is typically seen in response to conditions that increase afterload, such as hypertension.
**Why the Correct Answer is Right**
The correct answer is associated with conditions that lead to an increase in wall stress, causing the heart to adapt by thickening the wall. This is mediated by increased activity of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system, which leads to increased protein synthesis and cell growth. The increased wall thickness is primarily due to an increase in the number of contractile units (myocytes) and the extracellular matrix.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because eccentric hypertrophy, which involves an increase in chamber size without a proportional increase in wall thickness, is typically seen in conditions such as aortic regurgitation.
**Option B:** This option is incorrect because dilated cardiomyopathy, characterized by a decrease in contractility and chamber enlargement, is not associated with concentric hypertrophy.
**Option C:** This option is incorrect because restrictive cardiomyopathy, characterized by a stiff ventricle and impaired diastolic function, is not associated with concentric hypertrophy.
**Clinical Pearl / High-Yield Fact**
Concentric hypertrophy can lead to diastolic dysfunction and increased risk of heart failure with preserved ejection fraction (HFpEF) due to the stiffened ventricle.
**Correct Answer:** D. Hypertension