Concentric hyperophy of left ventricle is seen in –
**Core Concept**
Concentric hypertrophy of the left ventricle is a pathological condition characterized by an increase in the thickness of the left ventricular wall due to an increase in the number of myofibrils, leading to an augmentation of left ventricular wall mass without a significant increase in chamber size. This type of hypertrophy is often a compensatory response to increased afterload, which can be caused by hypertension or aortic stenosis.
**Why the Correct Answer is Right**
In concentric hypertrophy, the left ventricle increases in wall thickness to maintain a normal or near-normal chamber size, which is a compensatory mechanism to counteract the increased afterload. This process involves an increase in the expression of genes involved in the synthesis of contractile proteins, such as actin and myosin, leading to an increase in the number of myofibrils and ultimately, an increase in left ventricular wall mass. The concentric hypertrophy is often associated with a decrease in left ventricular compliance, making it more difficult for the left ventricle to relax and fill during diastole.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because eccentric hypertrophy is a different pathological condition characterized by an increase in left ventricular volume with a relatively normal wall thickness. This type of hypertrophy is often seen in conditions such as heart failure with preserved ejection fraction.
**Option B:** This option is incorrect because dilated cardiomyopathy is a condition characterized by an increase in left ventricular volume with a thinning of the left ventricular wall, which is the opposite of concentric hypertrophy.
**Option C:** This option is incorrect because restrictive cardiomyopathy is a condition characterized by a stiff left ventricle with a normal or near-normal left ventricular volume, but with impaired diastolic filling.
**Clinical Pearl / High-Yield Fact**
In the early stages of concentric hypertrophy, the left ventricle may maintain a normal or near-normal ejection fraction, making it a challenging condition to diagnose. However, as the disease progresses, the left ventricle may eventually develop symptoms of heart failure, such as shortness of breath and fatigue.
**Correct Answer:** A. Hypertension