**Core Concept**
The potency of steroids can vary based on their chemical structure, particularly the presence of a double bond between the 1 and 2 carbon atoms, known as an **A-ring double bond**. This modification affects the molecule's ability to penetrate cell membranes and interact with the cytoplasmic receptors. The potency of steroids can be influenced by their lipophilicity, which is determined by the presence of this double bond.

**Why the Correct Answer is Right**
Steroids with an A-ring double bond, such as **prednisolone**, are more potent than those without it, such as **prednisone**. This increased potency is due to the enhanced lipophilicity of the steroid, allowing it to more easily cross the cell membrane and bind to the glucocorticoid receptor. Once bound, the steroid-receptor complex can translocate to the nucleus, where it regulates gene expression and exerts its therapeutic effects.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is not provided, but it would be incorrect if it were a steroid without an A-ring double bond.
**Option B:** This option is not provided, but it would be incorrect if it were a non-steroidal compound.
**Option C:** This option is not provided, but it would be incorrect if it were a steroid with an A-ring double bond but at a lower concentration than the correct answer.

**Clinical Pearl / High-Yield Fact**
When choosing between steroids, remember that the presence of an A-ring double bond significantly increases potency. This is a crucial consideration when selecting a steroid for therapeutic use, as it can affect the required dosage and potential side effects.

**Correct Answer: C. Steroids with an A-ring double bond are more potent.**