Components of innate immunity that are active against viral cells includes:
Correct Answer: NK cells
Description: Properties of natural killer cells
Large granular lymphocytes.
Lack T-cell receptor, CD3 proteins, and surface IgM and IgD.
Prior exposure does not increase the activity.
Thymus is not required for development.
Number remains normal in severe combined immunodeficiency disease.
Functions of natural killer cells
Kill virus-infected cells and tumor cells.
Nonspecific killing of virus-infected cells and tumor cells.
Killing is independent of antigen presentation by MHC proteins.
Mechanism of killing is by perforins and granzymes, which cause apoptosis of target cell.
Killing is activated by failure of a cell to present antigen with class I MHC or by reduction of class I MHC proteins on the cell surface.
Parija SC. Textbook of Microbiology & Immunology. Elsevier Health Sciences; 2014. Page:131
Category:
Microbiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now