Complimentary sequence of 5′ GCACC 3′
**Question:** Complimentary sequence of 5' GCACC 3'
**Core Concept:** Complementary base pairing in DNA/RNA
In molecular biology, DNA and RNA molecules contain nucleotides with specific chemical structures that allow for complementary base pairing. The correct complementary sequence for the given 5' GCACC 3' is determined by matching the bases' chemical structures, which consists of a sugar (deoxyribose for DNA, ribose for RNA), a phosphate group, and a nitrogenous base.
**Why the Correct Answer is Right:**
The correct complementary sequence for the given 5' GCACC 3' is:
1. Guanine (G) pairs with Cytosine (C). In the given sequence, G is present at the 5' end and C at the 3' end.
2. Adenine (A) pairs with Thymine (T). In the given sequence, A is present at the 5' end and T at the 3' end.
By pairing these nucleotides accordingly, we obtain the correct complementary sequence: 5' CGACC 3'.
**Why Each Wrong Option is Incorrect:**
A. 5' GTGC 3' - This option does not maintain the correct pairing of G-C and A-T.
B. 5' ATCC 3' - This option also does not maintain the correct pairing of G-C and A-T.
C. 5' TAGC 3' - This option maintains the correct pairing of A-T but not G-C.
D. 5' GCTA 3' - This option maintains the correct pairing of G-C but not A-T.
**Core Concept:**
In biological molecules like DNA and RNA, the base pairing follows the principles of complementary base pairing:
1. Guanine (G) pairs with Cytosine (C), forming hydrogen bonds between N7 atoms of purines (A, G) and N3 atoms of pyrimidines (C, T).
2. Adenine (A) pairs with Thymine (T), forming hydrogen bonds between N1 atoms of purines (A, G) and N7 atoms of pyrimidines (T, C).
**Clinical Relevance:**
Understanding complementary base pairing is essential for understanding genetic information storage, transmission, and transcription/translation processes in cells.
**Why Each Wrong Option is Incorrect:**
A. Option A (GTGC) fails to maintain the correct pairing of G-C and A-T, which is crucial for maintaining genetic information stability and function.
B. Option B (ATCG) also fails to maintain the correct pairing of G-C and A-T, making it incorrect.
C. Option C (TCGA) maintains the correct pairing of G-C but not A-T, making it partially incorrect.
D. Option D (GCTA) maintains the correct pairing of G-C but not A-T, making it partially incorrect.
**Clinical Pearls:**
1. DNA and RNA are the genetic materials that store genetic information in cells.
2.