**Core Concept**
Streptokinase is a thrombolytic agent used to dissolve blood clots, particularly in acute ischemic stroke and myocardial infarction. Its administration can lead to various complications due to its mechanism of action, which involves activating the fibrinolytic pathway and inducing the conversion of plasminogen to plasmin.

**Why the Correct Answer is Right**
Joint pain is not a commonly reported complication of streptokinase. The other options are recognized side effects of streptokinase: intracranial bleed is a serious risk due to the potential for hemorrhagic transformation of ischemic brain tissue; anaphylaxis is a severe allergic reaction that can occur in some patients; and hypotension is a known side effect, possibly due to vasodilation or a decrease in blood volume.

**Why Each Wrong Option is Incorrect**
**Option B:** Intracranial bleed is indeed a complication of streptokinase, particularly in patients with a history of intracranial hemorrhage or those taking anticoagulants.
**Option C:** Anaphylaxis is a potential side effect of streptokinase, although it is rare. Symptoms include hypotension, tachycardia, and respiratory distress.
**Option D:** Hypotension is a recognized side effect of streptokinase, which can be managed with fluid replacement and vasopressors if necessary.

**Clinical Pearl / High-Yield Fact**
Streptokinase is a potent thrombolytic agent that should be used with caution in patients with a history of bleeding disorders, recent surgery, or trauma. Its administration should be closely monitored in a hospital setting to minimize the risk of complications.

**✓ Correct Answer: A. Joint pain**