**Core Concept**
A pancreatic pseudocyst is a fluid collection that forms in the abdomen as a result of pancreatitis, often following an episode of acute or chronic pancreatitis. The collection is usually surrounded by a wall of fibrous tissue and can mimic the appearance of a true cyst on imaging studies.

**Why the Correct Answer is Right**
Pseudocysts of the pancreas are generally not prone to the same complications as true cysts, such as rupture or malignant transformation. This is because pseudocysts are typically composed of a mixture of pancreatic enzymes, cellular debris, and inflammatory fluid, rather than a true epithelial lining. As a result, pseudocysts are less likely to rupture into the peritoneal cavity or to become infected.

**Why Each Wrong Option is Incorrect**
**Option A:** Rupture of a pseudocyst is a potential complication, but it is less likely to occur compared to a true cyst. This is because pseudocysts are typically surrounded by a wall of fibrous tissue that provides some degree of containment.
**Option B:** Malignant transformation of a pseudocyst is extremely rare and is more commonly associated with true cysts. Pseudocysts are not lined by epithelial cells, which are necessary for malignant transformation to occur.
**Option C:** Infection of a pseudocyst can occur, but it is less common than in true cysts. Pseudocysts are typically sterile, and infection is often a result of communication with the pancreatic duct or biliary system.
**Option D:** Obstruction of the pancreatic duct by a pseudocyst can occur, but it is less likely to be a complication compared to a true cyst.

**Clinical Pearl / High-Yield Fact**
Pseudocysts of the pancreas are often treated conservatively with drainage and antibiotics, rather than surgical intervention, due to the lower risk of complications.

**Correct Answer:** D.