The nucleotide triplet CTC in the sixth position of the l3-chain in DNA forms the complementary nucleotide on (mRNA) that codes for glutamic acid. A point mutation on the l3-chain resulting in the nucleotide triplet CAC forms a com¬plementary nucleotide on mRNA that codes for valine. In sickle cell anemia, you would expect the comple¬mentary nucleotide triplet on mRNA from 5′ to 3′ to read

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VB
Vikas Bhardwaj
Medical Technologist, AIIMS New Delhi
Updated: Apr 17, 2026