Using written convention, which one of the following sequences is complementary to TGGCAGCCT?
## **Core Concept**
The question tests understanding of **DNA base pairing rules**, which are fundamental to molecular biology. In DNA, adenine (A) pairs with thymine (T), and cytosine (C) pairs with guanine (G). This principle is crucial for replication, transcription, and other genetic processes.
## **Why the Correct Answer is Right**
The given DNA sequence is TGGCAGCCT. To find its complement, we apply the base pairing rules:
- T pairs with A
- G pairs with C
- G pairs with C
- C pairs with G
- A pairs with T
- G pairs with C
- C pairs with G
- C pairs with G
- T pairs with A
So, the complementary sequence to TGGCAGCCT is **ACCGTCGGA**.
## **Why Each Wrong Option is Incorrect**
- **Option A:** ACCGTCGGA is actually the correct complement, but let's evaluate the others.
- **Option B:** ACGCTCGAT - This sequence does not follow the base pairing rules correctly for the given sequence TGGCAGCCT.
- **Option C:** ACCGTGCTA - This also does not correctly pair with TGGCAGCCT.
- **Option D:** TGGCAGCCT - This is the original sequence, not its complement.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that in **RNA**, uracil (U) replaces thymine (T) and pairs with adenine (A). So, if you're looking for the RNA complement of a DNA sequence, you'd replace T with A, and A with U, but the base pairing rules remain similar.
## **Correct Answer:** . ACCGTCGGA