**Core Concept**
Hypospadias is a congenital anomaly of the male urethra, characterized by an incomplete closure of the urethral folds during embryonic development. This results in the urethral opening being located on the underside of the penis, rather than at the tip.

**Why the Correct Answer is Right**
The correct answer is **B. Glans**. This is because the majority of cases of hypospadias involve the urethral opening being located on the underside of the glans penis, also known as glandular hypospadias. This occurs due to the incomplete fusion of the urethral folds during fetal development, resulting in the urethral opening being displaced from its normal position at the tip of the penis.

**Why Each Wrong Option is Incorrect**
* **Option A:** This is incorrect because scrotal hypospadias, where the urethral opening is located on the underside of the scrotum, is a less common variant of the condition.
* **Option C:** This is incorrect because penoscrotal hypospadias, where the urethral opening is located on the junction between the penis and scrotum, is a more common variant, but not the most common.

**Clinical Pearl / High-Yield Fact**
It's essential to note that hypospadias can be associated with other congenital anomalies, such as undescended testes, epispadias, and chordee. A thorough examination and history-taking are crucial in the diagnosis and management of this condition.

**Correct Answer: B. Glans**