Commonest site of extraintestinal amoebiasis is –
**Core Concept**
The question tests knowledge of **extraintestinal amoebiasis**, which occurs when *Entamoeba histolytica* infection spreads beyond the intestines. This condition is a complication of intestinal amoebiasis.
**Why the Correct Answer is Right**
The liver is the most common site for extraintestinal amoebiasis due to the direct spread of the parasite through the portal vein from the intestines. *Entamoeba histolytica* can cause **liver abscesses**, which are collections of pus in the liver tissue.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because, although the brain can be affected by amoebiasis, it is a rare site for extraintestinal infection.
**Option B:** Incorrect as it is not the most common site.
**Option D:** Incorrect because, although other organs can be involved, they are less commonly affected than the liver.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that **liver abscess** is a common and serious complication of amoebiasis, often presenting with right upper quadrant abdominal pain and fever.
**Correct Answer:** D. Liver