Commonest Primary site of Kurkenberg tumour is:
**Core Concept**
The Krukenberg tumor is a type of metastatic tumor in the ovary, characterized by the presence of mucin-filled, signet-ring shaped cancer cells. It is essential to understand the **pathophysiology** of metastasis and the **histopathological** features of this tumor. The primary sites of Krukenberg tumors are usually **gastrointestinal** or **breast** cancers.
**Why the Correct Answer is Right**
The most common primary site of Krukenberg tumor is the **stomach**, accounting for approximately 70% of cases. This is because gastric adenocarcinoma, particularly the diffuse type, can metastasize to the ovaries, resulting in Krukenberg tumors. The **signet-ring cells** in these tumors are a hallmark of this type of metastasis.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because, although breast cancer can metastasize to the ovaries, it is not the most common primary site of Krukenberg tumors.
**Option B:** Incorrect as other primary sites like the colon or appendix are less common sources of Krukenberg tumors.
**Option D:** Incorrect because, although other sites can be involved, they are not the most common primary site of Krukenberg tumors.
**Clinical Pearl / High-Yield Fact**
It is crucial to distinguish between primary and metastatic ovarian tumors, as the treatment and prognosis differ significantly. A key point to remember is that Krukenberg tumors often present bilaterally and are associated with a poor prognosis.
**Correct Answer:** D. Stomach