Commonest manifestation of Grawitz’s tumor in male
**Core Concept**
Grawitz's tumor, also known as renal cell carcinoma, is a type of cancer that originates in the kidney. It is a malignant tumor that arises from the renal epithelium, and its manifestations can vary depending on the location and size of the tumor.
**Why the Correct Answer is Right**
The commonest manifestation of Grawitz's tumor in males is hematuria, which is the presence of blood in the urine. This occurs due to the erosion of the tumor into the renal pelvis or the calyces, resulting in the release of blood into the urinary tract. Hematuria is often the first symptom of renal cell carcinoma, and it is more common in males than in females. The tumor's ability to invade and destroy the surrounding kidney tissue can also lead to flank pain, weight loss, and fatigue.
**Why Each Wrong Option is Incorrect**
**Option A:** Although hypertension can be a manifestation of renal cell carcinoma, it is not the commonest manifestation in males.
**Option B:** Abdominal mass is a possible manifestation of Grawitz's tumor, but it is not the most common symptom in males.
**Option C:** Flank pain is a symptom of renal cell carcinoma, but it is not the most common manifestation in males.
**Clinical Pearl / High-Yield Fact**
Renal cell carcinoma is often associated with a palpable abdominal mass, but it is more commonly diagnosed incidentally on imaging studies, such as CT scans or ultrasounds, performed for unrelated reasons.
**Correct Answer: D. Hematuria**