Commonest cancer in males is-
**Core Concept**
Prostate cancer is the most common malignancy in males, with a rising incidence worldwide. This is attributed to the increasing lifespan of men, which allows more time for the development of this cancer.
**Why the Correct Answer is Right**
Prostate cancer arises from the epithelial cells of the prostate gland, with the majority of cases being adenocarcinomas. The exact cause of prostate cancer is unknown, but it is believed to involve a combination of genetic and environmental factors, including hormones such as testosterone and dihydrotestosterone (DHT). The androgen receptor plays a crucial role in the development and progression of prostate cancer.
**Why Each Wrong Option is Incorrect**
**Option A:** While lung cancer is a leading cause of cancer-related deaths in males, it is not the most common cancer in this demographic.
**Option B:** Colorectal cancer is a common malignancy, but it is more prevalent in females than in males.
**Option C:** Stomach cancer is a significant health burden in certain regions, but it is not the most common cancer in males globally.
**Clinical Pearl / High-Yield Fact**
The American Cancer Society recommends annual prostate-specific antigen (PSA) screening for men aged 55-69 years, highlighting the importance of early detection in reducing prostate cancer mortality.
**Correct Answer: A. Prostate cancer.**