Common antibody in Polymyositis and Dermatomyositis includes
Correct Answer: Anti-aminoacyl-tRNA synthetase
Description: (C) Anti-aminoacyl-tRNA synthetase# About 50% of patients with polymyositis or dermatomyositis have myositis-specific antibodies, so when the clinical exam and testing suggest the possibility of these diseases, the presence of these antibodies can be strong supporting evidence for the diagnosis.> There are literally dozens of myositis-specific and myositis-associated antibodies identified, and researchers are learning more about them.> Some of the best-known are anti-aminoacyl-tRNA synthetases, anti-Signal Recognition Particle (SRP), and anti-Mi-2: chromodomain helicase DNA binding protein 4.> Several studies have noted that these serological types are identified with differences in presentation and prognosis. Patients with anti-aminoacyl-tRNA synthetases may have arthritis in addition to myositis, fevers, interstitial lung disease and the "mechanic's hands" so named because of the thickening of the palms of the hands. Patients with anti-Signal Recognition Particle may have severe muscle weakness that comes on very rapidly, muscle aches, and cardiac involvement. Those with anti-Mi-2: chromodomain helicase DNA binding protein 4 may have the classic dermatomyositis skin signs, like the shawl rashes and cuticle overgrowth.
Category:
Pathology
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