## **Core Concept**
The question tests knowledge of specific autoantibodies associated with various autoimmune diseases. Autoantibodies are crucial for diagnosing and differentiating between autoimmune conditions. Each option presents a pair of autoantibodies, and the task is to identify which pair is used in diagnosing the same autoimmune disease.

## **Why the Correct Answer is Right**
The correct answer, option , refers to the combination of **Anti-SSA/Ro** and **Anti-SSB/La** autoantibodies. Both of these autoantibodies are specifically associated with **Sjögren's syndrome**, an autoimmune disease characterized by its effects primarily on the exocrine glands, notably the salivary and lacrimal glands, leading to symptoms of dry mouth (xerostomia) and dry eyes (xerophthalmia). These autoantibodies are among the diagnostic criteria for Sjögren's syndrome and are considered hallmark antibodies for this condition.

## **Why Each Wrong Option is Incorrect**
- **Option A:** This option might include autoantibodies not both specific to the same disease, such as **Anti-dsDNA** and **Anti-SSA/Ro**. While **Anti-SSA/Ro** can be seen in Sjögren's syndrome, **Anti-dsDNA** is more specific to **Systemic Lupus Erythematosus (SLE)**.
- **Option B:** Similarly, this could involve **Anti-Jo-1** and **Anti-SSB/La**, where **Anti-Jo-1** is associated with **Polymyositis** and **Dermatomyositis**, particularly with anti-synthetase syndrome, and not specifically with Sjögren's syndrome alone.
- **Option D:** This option might pair autoantibodies like **Anti-centromere** and **Anti-Scl-70 (Topoisomerase I)**, both of which are seen in **Systemic Sclerosis (Scleroderma)** but are associated with different subsets of the disease (limited vs. diffuse systemic sclerosis).

## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that **Sjögren's syndrome** can be primary (isolated) or secondary (associated with another connective tissue disease). The presence of **Anti-SSA/Ro** and **Anti-SSB/La** autoantibodies supports the diagnosis of Sjögren's syndrome, with **Anti-SSB/La** being more specific. These autoantibodies can also be seen in SLE and other autoimmune diseases but are particularly associated with Sjögren's.

## **Correct Answer: C.**