Clostridium difficile causes –
Correct Answer: Pseudomembranous colitis
Description: Ans. is 'a' i.e., Pseudomembranous colitis & 'b' i.e., Nosocomical diarrhea * Cl difficle causes Clostridium difficle - associated diseases (CDAD).* CDAD is the most commonly diagnosed diarrheal illness acquired in the hospital.* C. difficle is acquired exogenously, most frequently in the hospital.* C. difficle is the most common bacterial cause of nosocomial diarrhea.* Diarrhea is the most common symptom of CDAD.* Pseudomembranous colitis is the advanced form of CDAD.* CDAD is almost exclusively associated with antibiotic use. It is caused most commonly by 2nd generation cephalospirinsy clindamycin, ampicillin and fluoroquinolones.* Other important risk factors (beside antibiotic use) are old age, GI surgery, use of electrical thermometer, use of antacids and PPIs, and prolonged hospital stay.* Pseudomembranous colitis is caused by two large toxins of Cl difficle1) Toxin A (enterotoxin) : Causes disruption of cystoskeleton by glycosylation of GTP-binding proteins.2) Toxin B (cytotoxin) : Has effect similar to toxin A.
Category:
Microbiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now