Chrugstrauss involves following except ?
**Core Concept**
Chrugstrauss syndrome, also known as eosinophilic granulomatosis with polyangiitis (EGPA), is a rare autoimmune disorder characterized by the presence of eosinophils and granulomas in affected tissues. It is a type of vasculitis that affects small- and medium-sized blood vessels, particularly those in the lungs and gastrointestinal tract.
**Why the Correct Answer is Right**
The correct answer involves identifying the characteristic features of Chrugstrauss syndrome. EGPA is characterized by the presence of eosinophils, which are a type of white blood cell involved in the body's allergic response. The syndrome also involves the formation of granulomas, which are clusters of immune cells that accumulate in response to inflammation. The combination of eosinophilia and granulomatosis is a hallmark of EGPA.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Chrugstrauss syndrome is not typically associated with lymphocytic infiltration, which is more characteristic of other types of vasculitis.
**Option B:** This option is incorrect because Chrugstrauss syndrome can involve the lungs, but it is not primarily a disease of the lungs. The lungs are one of the most commonly affected organs in EGPA, but the disease can also affect other parts of the body, including the skin, kidneys, and gastrointestinal tract.
**Option C:** This option is incorrect because Chrugstrauss syndrome is not typically associated with necrotizing vasculitis, which is a more aggressive form of vasculitis characterized by the destruction of blood vessel walls.
**Option D:** This option is incorrect because Chrugstrauss syndrome is not typically associated with rheumatoid factor, which is an antibody that is often present in patients with rheumatoid arthritis.
**Clinical Pearl / High-Yield Fact**
One key feature of Chrugstrauss syndrome is the presence of asthma, which is often a precursor to the development of EGPA. Patients with asthma are at increased risk of developing EGPA, and the presence of asthma should raise suspicion for this diagnosis in patients with unexplained eosinophilia or granulomatosis.
**Correct Answer:** D.