Chronic HIV infection is associated with which typical nephropathy?
Correct Answer: Collapsing variant of Focal Segmental glomerulosclerosis
Description: Ans. c (Collapsing variant of Focal Segmental glomerulosclerosis) (Ref. Robbin's 8th/555; Harrison's 17th/Ch. 277)Collapsing glomerulopathy is characterized by collapse of the entire glomerular tuft and podocyte hyperplasia. This is a more severe manifestation of FSGS that may be idiopathic or associated with HIV infection or drug-induced toxicities. It carries a particularly poor prognosis.HUMAN IMMUNODEFICIENCY VIRUS ASSOCIATED NEPHROPATHY# HIV-associated nephropathy is seen after an interval of approximately 2.5 years from discovery of HIV, and many patients have low CD4 counts.# Most lesions on renal biopsy show FSGS followed by MPGN. Other less common renal lesions include DPGN, IgA nephropathy, MCD, and membranous or mesangioproliferative glomerulonephritis.# The FSGS characteristically reveals collapse of the glomerular capillary tuft called collapsing glomerulopathy. visceral epithelial cell swelling, microcystic dilatation of renal tubules, and tubuloreticular inclusions.# MPGN and DPGN have been reported more commonly in HIV-infected Caucasians and in patients co-infected with hepatitis B or C. HIV-associated TTP has also been reported.# HIV with FSGS typically present with nephrotic-range proteinuria and hypoalbuminemia, but unlike patients with other causes for nephrotic syndrome, they do not have HTN, edema, or hyperlipidemia.# Rx with inhibitors of the renin-angiotensin system decreases the proteinuria.# Many feel that effective antiretroviral therapy benefits both the patient and the kidney.
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now