Chronic Active Hepatitis can be best differentiated from Chronic Persistant Hepatitis by:
Correct Answer: Histopathology
Description: Answer is C (Histopathology): Chronic Active Hepatitis and Chronic Persistant Hepatitis (CPH) are histopathological classification systems for various forms of chronic hepatitis based on findings on biopsy specimens. This classification system is however obsolete now and should not be used. Histopathological Classification of Chronic Hepatitis Chronic Active Hepatitis (Peripoal or Interface Hepatitis) Chronic Hepatitis with histopathological features suggesting a progressive course Biopsy Features Hepatic architecture is distoed Inflammation extends beyond the poal tract (Poal tract infiltration is common with early poal tract fibrosis) Lamina Limitans is breached and hepatic lobules are invaded Piecemeal necrosis & bridging necrosis is typically seen in Lobules Chronic Persistant Hepatitis (Poal Hepatitis) Chronic Hepatitis with histopathological features suggesting a beingn and self limiting course Biopsy Features Hepatic architecture is maintained Inflammation is limited to poal tracts (Poal tract infiltration is typical but poal tract fibrosis is minimal) Minimal/No breach of Lamina Limitans Minimal /No Piecemeal necrosis or Bridging necrosis in Lobules
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