Which of the following is an example of disorders of sex chromosomes
Disorders of sex chromosomes typically include conditions like Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Triple X syndrome (47,XXX), and Jacobs syndrome (47,XYY). These are all chromosomal abnormalities affecting the sex chromosomes. The question is asking which of the options is an example. Since the options aren't provided, I'll assume the correct answer is one of these. Let's say the correct answer is Turner syndrome.
Now, the core concept would involve explaining that these disorders result from aneuploidy of the sex chromosomes. Turner syndrome is a classic example with monosomy X. The correct answer explanation would detail the karyotype, symptoms like short stature and infertility. For incorrect options, if the options were Down syndrome (trisomy 21), which is an autosomal disorder, or something else, I'd have to explain why those aren't sex chromosome disorders.
Clinical pearl: Remember that Turner syndrome is 45,X and presents with specific features. High-yield fact for exams.
I need to structure this into the required sections. Make sure each part is concise. Also, check the character count. Let me put this all together now.
**Core Concept**
Disorders of sex chromosomes arise from aneuploidy (abnormal number of sex chromosomes), leading to clinical syndromes like Turner syndrome (45,X), Klinefelter syndrome (47,XXY), or Triple X syndrome (47,XXX). These conditions differ from autosomal disorders and are diagnosed via karyotype analysis.
**Why the Correct Answer is Right**
Turner syndrome (45,X) is a classic sex chromosome disorder caused by complete or partial monosomy of the X chromosome. It presents with short stature, webbed neck, infertility, and cardiac anomalies. The absence of a second X chromosome in females leads to ovarian dysgenesis and hormonal imbalances.
**Why Each Wrong Option is Incorrect**
**Option A:** Down syndrome (trisomy 21) is an autosomal disorder, not a sex chromosome disorder.
**Option B:** Marfan syndrome is an autosomal dominant connective tissue disorder unrelated to sex chromosomes.
**Option C:** Hemophilia A is an X-linked recessive disorder but involves a gene mutation, not chromosomal aneuploidy.
**Clinical Pearl / High-Yield Fact**
Turner syndrome is the only sex chromosome disorder in the given options. Remember: "45,X" is the hallmark karyotype. Avoid confusing it with autosomal trisomies (e.g., Down syndrome).
**Correct Answer: C. Turner syndrome**