RET proto oncogene is located on which chromosome:

**Core Concept**
The RET proto-oncogene is a tumor suppressor gene involved in the development of certain cancers, particularly multiple endocrine neoplasia type 2 (MEN2). It plays a crucial role in the regulation of cell growth and division by encoding a receptor tyrosine kinase involved in the signaling pathway of the glial cell line-derived neurotrophic factor (GDNF).

**Why the Correct Answer is Right**
The RET proto-oncogene is located on the long arm of chromosome 10 (10q11.2). This gene is essential for the proper development and function of the kidneys, thyroid, and other endocrine glands. Mutations in the RET gene can lead to the development of MEN2, a hereditary condition characterized by the occurrence of medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism. The correct localization of the RET proto-oncogene on chromosome 10 is crucial for understanding its role in cancer development and diagnosis.

**Why Each Wrong Option is Incorrect**
**Option A:** Chromosome 9 is not associated with the RET proto-oncogene, although it does contain other genes involved in cancer susceptibility, such as the TP53 tumor suppressor gene.
**Option C:** Chromosome 11 is known for containing the genes for the Wilms tumor suppressor (WT1) and the von Willebrand factor (VWF), but not the RET proto-oncogene.
**Option D:** Chromosome 12 is associated with various genes, including the ETV6 gene involved in leukemias, but not the RET proto-oncogene.

**Clinical Pearl / High-Yield Fact**
The RET proto-oncogene is a classic example of a tumor suppressor gene, which, when mutated, can lead to the development of cancer. Understanding the genetic basis of cancer is essential for developing targeted therapies and improving patient outcomes.

✓ Correct Answer: B. 10