Deletion of short arm of 5th chromosome is___ syndrome
## **Core Concept**
The question pertains to a specific genetic disorder associated with a chromosomal deletion. The deletion of the short arm of the 5th chromosome is linked to a well-known syndrome in medical genetics.
## **Why the Correct Answer is Right**
The deletion of the short arm of chromosome 5 is associated with **Cri-du-chat syndrome**. This syndrome is a genetic disorder caused by a partial deletion of the short arm (p) of chromosome 5. The name "Cri-du-chat" is French for "cry of the cat," which refers to the distinctive high-pitched cry that infants with this condition often have. The syndrome is characterized by a range of physical and developmental features, including a high-pitched cry, wide-set eyes (hypertelorism), a small jaw (micrognathia), and developmental delays.
## **Why Each Wrong Option is Incorrect**
- **Option A:** Not provided, but presumably incorrect based on the context.
- **Option B:** Not provided, but presumably incorrect based on the context.
- **Option C:** Not provided, but presumably incorrect based on the context.
## **Clinical Pearl / High-Yield Fact**
A key clinical feature of Cri-du-chat syndrome is the **high-pitched cry** that sounds similar to that of a cat. This is a critical diagnostic clue and a memorable aspect of the syndrome. Additionally, individuals with Cri-du-chat syndrome often have **intellectual disability** and **distinctive facial features**.
## **Correct Answer:** . Cri-du-chat syndrome