**Core Concept**
The question tests knowledge of tumor locations within bones, specifically focusing on the metaphysis, which is the wide portion of a long bone where the growth plate is located. **Bone tumors** can be benign or malignant and have specific sites of origin within the bone. Understanding the typical locations of various bone tumors is crucial for diagnosis and treatment.

**Why the Correct Answer is Right**
The correct answer includes **Osteosarcoma**, **Osteoclastoma**, and **Ewing's sarcoma**, all of which are known to occur in the metaphysis. **Osteosarcoma** is the most common primary malignant bone tumor, typically arising in the metaphyseal regions of long bones. **Ewing's sarcoma** is another malignant tumor that often originates in the metaphysis of long bones. **Osteoclastoma (Giant Cell Tumor)**, although more commonly associated with the epiphysis, can also extend into the metaphysis.

**Why Each Wrong Option is Incorrect**
**Option A:** Osteomyelitis is an infection of the bone and is not a tumor.
**Option C:** Chondrosarcoma typically arises from the cartilage and is more commonly found in the medullary cavity or on the surface of bones, rather than specifically in the metaphysis.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that the location of a bone tumor can significantly influence its diagnosis and treatment plan. For instance, **Ewing's sarcoma** and **Osteosarcoma** are both aggressive tumors that require prompt and specific treatments, including chemotherapy and surgery.

**Correct Answer:** D. Osteosarcoma, Osteoclastoma, Ewing's sarcoma.