**Question:** Cholesterol is a predominant lipid in

A. Brain
B. Liver
C. Skin
D. Chylomicrons

**Core Concept:** Cholesterol is a vital component of cell membranes, a precursor for steroid hormones, and plays a role in bile acid synthesis. It is primarily derived from the diet and synthesized in the liver.

**Why the Correct Answer is Right:** Cholesterol is a predominant lipid in liver (Option B) because the liver plays a crucial role in cholesterol homeostasis, synthesizing and regulating cholesterol levels in the body.

**Why Each Wrong Option is Incorrect:**

Option A (Brain) is incorrect because the brain predominantly contains phospholipids and gangliosides in its cell membranes, not cholesterol.

Option C (Skin) is incorrect because the skin primarily consists of phospholipids in the epidermal and dermal layers, not cholesterol.

Option D (Chylomicrons) is incorrect because Chylomicrons are lipoprotein particles involved in the transport of dietary fat, not cholesterol.

**Clinical Pearl:** The World Health Organization (WHO) recommends a daily intake of no more than 300 mg of cholesterol for adults to maintain optimal health and prevent hypercholesterolemia-related diseases like atherosclerosis and cardiovascular disorders.

**Correct Answer:** Liver