**Core Concept**
In elective laparoscopic cholecystectomy with no gross spillage, the primary concern is preventing surgical site infections (SSIs) without unnecessarily exposing patients to antibiotics. The principle behind this is to minimize antibiotic resistance and maintain the delicate balance of the gut microbiome.

**Why the Correct Answer is Right**
A single dose of preoperative IV antibiotic is sufficient for preventing SSIs in clean-contaminated surgeries like lap cholecystectomy, where the risk of bacterial contamination is low. This approach is based on the concept of 'anticipatory prophylaxis', where antibiotics are administered before the start of surgery to prevent potential contamination. The recommended antibiotic choice is typically a broad-spectrum agent, such as cefotetan or cefazolin. The duration of antibiotic prophylaxis is generally limited to the time of surgical exposure, which in this case is a single dose.

**Why Each Wrong Option is Incorrect**
**Option A:** Administering a 5-day course of oral antibiotics is unnecessary and may contribute to the development of antibiotic resistance. This approach is more appropriate for postoperative prophylaxis in high-risk surgeries with significant contamination.
**Option B:** Postoperative IV antibiotics for 1 day followed by oral antibiotics may be required for high-risk surgeries with significant contamination, but it is not necessary for elective lap cholecystectomy with no gross spillage.
**Option D:** A 5-day course of oral antibiotics alone is not sufficient for preventing SSIs in clean-contaminated surgeries like lap cholecystectomy.

**Clinical Pearl / High-Yield Fact**
For clean-contaminated surgeries like lap cholecystectomy, a single dose of preoperative IV antibiotic is sufficient for preventing SSIs. This approach should be tailored to the individual patient's risk factors and the specific surgical procedure being performed.

✓ Correct Answer: C. Single dose of Preoperative IV antibiotic only.