**Core Concept**
Chloroquine is an antimalarial drug that belongs to the 4-aminoquinoline class. It works by interfering with the heme detoxification process in the malaria parasite, ultimately leading to its death.
**Why the Correct Answer is Right**
Chloroquine acts by accumulating in the food vacuole of the malaria parasite, where it inhibits the polymerization of hemoglobin, leading to the formation of toxic heme pigments. This disrupts the parasite's ability to detoxify heme, ultimately causing its death. Chloroquine also has immunomodulatory effects, which can help in treating autoimmune diseases.
**Why Each Wrong Option is Incorrect**
**Option A:** Chloroquine is not typically used for treating tuberculosis. **Option B:** Chloroquine is not a first-line treatment for typhoid fever. **Option C:** Chloroquine is not used for treating viral infections like HIV or influenza.
**Clinical Pearl / High-Yield Fact**
Chloroquine is also used in the treatment of autoimmune diseases like lupus and rheumatoid arthritis, due to its immunomodulatory effects. However, its use in these conditions is often limited by its potential to cause retinal toxicity at higher doses.
**Correct Answer: C. Malaria.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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