**Core Concept**
Scabies is a parasitic skin infestation caused by the mite Sarcoptes scabiei. In infants, scabies presents differently due to the unique characteristics of their skin and immune response.

**Why the Correct Answer is Right**
In infants, scabies tends to affect the palms and soles, which is in contrast to adults and children where it typically affects the finger webs, wrists, and genital areas. This difference is due to the thinner skin and higher concentration of sensory nerve endings in infants' palms and soles. The intense itching sensation in infants is often more pronounced in these areas, making it a key distinguishing feature of scabies in this age group.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not accurately describe the unique presentation of scabies in infants.
**Option B:** This option is incorrect as it is a general characteristic of scabies in all age groups, not specific to infants.
**Option C:** This option is incorrect as it is a treatment-related consideration, not a distinguishing feature of scabies in infants.

**Clinical Pearl / High-Yield Fact**
Infants with scabies often present with intense itching, particularly at night, and may exhibit other systemic symptoms such as fever and irritability.

**Correct Answer: D. The palms and soles.**