The chestnut coloured fungal cells known as muriform bodies are seen in:
**Core Concept**
Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue, primarily caused by several species of fungi in the genera Fonsecaea, Phialophora, and Cladophialophora. The disease is characterized by the presence of distinctive fungal cells known as muriform bodies or sclerotic bodies.
**Why the Correct Answer is Right**
Muriform bodies are a key diagnostic feature of chromoblastomycosis. These cells are thick-walled, darkly pigmented, and have a characteristic "muriform" or "board-like" appearance under microscopic examination. They are formed as a result of the fungal cell's attempt to protect itself from the host's immune response. The muriform bodies are typically 20-40 micrometers in size and have a distinct, chestnut-brown color.
**Why Each Wrong Option is Incorrect**
**Option A:** Sporotrichosis is a different fungal infection caused by Sporothrix schenckii, which typically presents with cutaneous or lymphocutaneous lesions. It does not feature muriform bodies.
**Option B:** Phaeohyphomycosis is a group of fungal infections caused by dematiaceous (pigmented) fungi, which can present with a range of clinical manifestations, including skin lesions. However, it is not characterized by the presence of muriform bodies.
**Option D:** Lobomycosis is a rare fungal infection caused by Loboa loboi, which primarily affects the skin and subcutaneous tissue of the face and ears. It does not feature muriform bodies.
**Clinical Pearl / High-Yield Fact**
It is essential for clinicians to recognize the distinctive appearance of muriform bodies in tissue samples to diagnose chromoblastomycosis. This can be achieved through histopathological examination using a combination of hematoxylin and eosin (H&E) staining and periodic acid-Schiff (PAS) staining.
**β Correct Answer: C. Chromoblastomycosis**