**Core Concept**
Ewing's sarcoma is a malignant bone tumor primarily affecting children and young adults, characterized by a specific chromosomal translocation involving the EWS gene. The treatment of Ewing's sarcoma involves a combination of chemotherapy, radiation therapy, and surgery. Chemotherapy plays a crucial role in the management of Ewing's sarcoma, aiming to control the tumor and prevent recurrence.

**Why the Correct Answer is Right**
Chemotherapy regimens for Ewing's sarcoma typically include anthracyclines, such as doxorubicin, and platinum-based agents, like cisplatin. Other chemotherapeutic agents like etoposide, cyclophosphamide, and vincristine are also used in various combinations. These agents target rapidly dividing cancer cells, aiming to control the tumor and prevent metastasis.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a chemotherapeutic agent commonly used in the treatment of Ewing's sarcoma.
**Option B:** This option is incorrect because it is a chemotherapeutic agent that can be used in the treatment of Ewing's sarcoma, although it is not as commonly used as other agents.
**Option C:** This option is incorrect because it is a chemotherapeutic agent that is not typically used in the treatment of Ewing's sarcoma.

**Clinical Pearl / High-Yield Fact**
The most effective chemotherapy regimen for Ewing's sarcoma often involves a combination of anthracyclines and platinum-based agents, such as VDC/IE (vincristine, doxorubicin, and cyclophosphamide, followed by ifosfamide and etoposide).

**Correct Answer: C.**