50 years old man came with complaint of fever and pain in abdomen for past one week. Ultrasound of abdomen was performed which revealed a hypoechoic lesion in liver. CECT was done to characterize the lesion . Which of the following statement is false regarding the lesion?

**Core Concept**
The question is testing the student's knowledge of liver lesions, specifically the characteristics and imaging features of various types of liver lesions.

**Why the Correct Answer is Right**
CECT (Contrast-Enhanced Computed Tomography) is a crucial imaging modality for characterizing liver lesions. The statement that will be false regarding the lesion will be related to its enhancement pattern on CECT. The enhancement patterns of liver lesions are crucial for differentiating between benign and malignant lesions. Typically, malignant lesions like hepatocellular carcinoma (HCC) show early arterial enhancement followed by washout in the portal venous phase. On the other hand, benign lesions like hemangiomas show peripheral nodular enhancement followed by centripetal filling in the portal venous phase.

**Why Each Wrong Option is Incorrect**
* **Option A:** This statement could be true depending on the type of liver lesion. Some liver lesions like hepatocellular adenoma may show early arterial enhancement followed by washout in the portal venous phase.
* **Option B:** This statement is false regarding the lesion. Hemangiomas typically show peripheral nodular enhancement on CECT, not homogeneous enhancement.
* **Option C:** This statement could be true depending on the type of liver lesion. Some liver lesions like metastases from colorectal cancer may show heterogeneous enhancement on CECT.
* **Option D:** This statement could be true depending on the type of liver lesion. Some liver lesions like focal nodular hyperplasia (FNH) may show homogeneous enhancement on CECT.

**Clinical Pearl / High-Yield Fact**
When characterizing liver lesions on CECT, remember the "Brixia" rule: benign lesions typically show peripheral nodular enhancement (B), whereas malignant lesions show early arterial enhancement (R) followed by washout (I) in the portal venous phase (X) and a hypodense center (A).

**Correct Answer: B. Hemangiomas typically show peripheral nodular enhancement on CECT, not homogeneous enhancement.**

✓ Correct Answer: C. Hematogeneous route is the most common source of infection.