**Core Concept**
Sarcoidosis is a systemic granulomatous disease characterized by the formation of non-caseating granulomas in various organs, particularly the lungs, lymph nodes, and skin. It is a complex disease involving an interplay between genetic predisposition, environmental triggers, and immune system dysregulation.

**Why the Correct Answer is Right**
Sarcoidosis typically presents with a wide range of clinical manifestations, including respiratory symptoms, skin lesions, and systemic symptoms such as fever and weight loss. The disease is often associated with hypercalcemia due to increased vitamin D activation by macrophages within granulomas, leading to increased intestinal calcium absorption. Additionally, sarcoidosis can cause hypergammaglobulinemia, anemia, and elevated angiotensin-converting enzyme (ACE) levels.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is actually a characteristic association with sarcoidosis.
**Option B:** This option is incorrect because it is also a characteristic association with sarcoidosis.
**Option D:** This option is incorrect because it is indeed related to sarcoidosis, which often presents with systemic symptoms such as fever and weight loss.

**Clinical Pearl / High-Yield Fact**
In sarcoidosis, the presence of non-caseating granulomas is a hallmark feature, which can be identified on histopathological examination. It is essential to differentiate sarcoidosis from other granulomatous diseases, such as tuberculosis and histoplasmosis, which typically present with caseating granulomas.

**Correct Answer: D.** This option is not characteristically associated with sarcoidosis, as it is more commonly related to other conditions.