Lung is characteristically involved in –
**Core Concept**
Churg-Strauss syndrome, also known as eosinophilic granulomatosis with polyangiitis (EGPA), is a rare autoimmune disorder characterized by the presence of asthma, eosinophilia, and vasculitis. The involvement of the lungs in Churg-Strauss syndrome is a hallmark of the disease, often presenting with pulmonary infiltrates, eosinophilic pneumonia, and asthma.
**Why the Correct Answer is Right**
The pathophysiology of Churg-Strauss syndrome involves the activation of eosinophils, which are a type of white blood cell that plays a crucial role in the body's immune response. In this condition, eosinophils are overactivated, leading to the release of granules that cause tissue damage and inflammation. The lungs are particularly susceptible to the effects of eosinophilic granulomatosis, resulting in the characteristic pulmonary involvement. The presence of eosinophils in the lung tissue is a key diagnostic feature of Churg-Strauss syndrome.
**Why Each Wrong Option is Incorrect**
**Option B:** HSP (Henoch-Schönlein purpura) is a form of vasculitis that primarily affects the skin, kidneys, and gastrointestinal tract, but it does not typically involve the lungs.
**Option C:** PAN (Polyarteritis nodosa) is a form of vasculitis that affects medium-sized blood vessels, but it is more commonly associated with renal and gastrointestinal involvement rather than pulmonary involvement.
**Option D:** ITP (Immune thrombocytopenic purpura) is an autoimmune disorder characterized by low platelet count, but it does not typically involve the lungs.
**Clinical Pearl / High-Yield Fact**
Churg-Strauss syndrome often presents with a triad of asthma, eosinophilia, and vasculitis, making it a critical condition to consider in patients with these symptoms.
✓ Correct Answer: A. Churg-Strauss syndrome