**Core Concept**
Ewing's sarcoma is a malignant bone tumor characterized by a specific chromosomal translocation involving the EWS gene. This genetic abnormality plays a crucial role in the pathogenesis of the disease.

**Why the Correct Answer is Right**
The characteristic translocation in Ewing's sarcoma involves the fusion of the EWS gene on chromosome 22 with one of several partner genes, most commonly FLI1 on chromosome 11. This fusion creates a chimeric protein that acts as a potent transcriptional activator, leading to the aberrant expression of genes involved in cell proliferation and survival. The EWS-FLI1 fusion protein is considered a hallmark of Ewing's sarcoma and is used as a diagnostic marker.

**Why Each Wrong Option is Incorrect**
**Option A:** t(2;16) - This translocation is not typically associated with Ewing's sarcoma.
**Option B:** t(11;14) - This translocation is more commonly seen in mantle cell lymphoma.
**Option C:** t(9;22) - This translocation is characteristic of chronic myeloid leukemia (CML), also known as the Philadelphia chromosome.

**Clinical Pearl / High-Yield Fact**
Ewing's sarcoma is a highly malignant tumor that often presents with systemic symptoms such as fever, weight loss, and anemia. The EWS-FLI1 fusion protein is a critical diagnostic marker, and its detection is essential for the diagnosis of Ewing's sarcoma.

**Correct Answer: C. t(9;22)**