Goodpasture’s disease is characteraized by all except-
**Core Concept**
Goodpasture's disease is a rare autoimmune disorder characterized by the presence of autoantibodies against the glomerular and alveolar basement membranes. It is also known as anti-glomerular basement membrane (anti-GBM) disease. The disease involves the kidneys and lungs, leading to rapidly progressive glomerulonephritis and diffuse alveolar hemorrhage.
**Why the Correct Answer is Right**
The correct answer, B. Leukocytoclastic vasculitis, is incorrect because Goodpasture's disease is primarily characterized by the presence of anti-GBM antibodies, which target the type IV collagen in the basement membranes of the glomeruli and alveoli. This leads to a linear pattern of immunofluorescence on renal biopsy. The disease is not typically associated with leukocytoclastic vasculitis, which is a feature of other types of vasculitis, such as granulomatosis with polyangiitis.
**Why Each Wrong Option is Incorrect**
**Option A:** Glomerulonephritis is a correct feature of Goodpasture's disease, as the anti-GBM antibodies cause inflammation and damage to the glomeruli.
**Option C:** Presence of antibodies to BM is also a correct feature, as the disease is defined by the presence of these autoantibodies.
**Option D:** Diffuse alveolar hemorrhage is another characteristic feature of Goodpasture's disease, resulting from the damage to the alveolar basement membranes.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that Goodpasture's disease typically presents with a combination of renal and pulmonary symptoms, and the diagnosis is often made by detecting anti-GBM antibodies in the serum.
**β Correct Answer: B. Leukocytoclastic vasculitis**