All of the following changes in liver are seen in Wilson’s disease, EXCEPT
**Core Concept**
Wilson's disease is a rare genetic disorder characterized by excessive accumulation of copper in the body, particularly in the liver and brain. This accumulation leads to liver damage, neurological symptoms, and psychiatric problems. The liver histology in Wilson's disease shows a characteristic feature of copper deposition.
**Why the Correct Answer is Right**
Wilson's disease is associated with the accumulation of copper in the liver, which leads to liver damage. The liver histology in Wilson's disease shows a characteristic feature of copper deposition, including **periportal fibrosis**, **macronodular cirrhosis**, and **hemosiderin deposition**. The liver also shows **steatosis** and **inflammation** due to the toxic effects of excess copper.
**Why Each Wrong Option is Incorrect**
**Option A:** **Kupffer cell hypertrophy** is indeed seen in Wilson's disease, as the liver's reticuloendothelial system tries to remove the excess copper. This is a correct association.
**Option B:** **Mallory-Denk bodies** are actually seen in alcoholic liver disease, not Wilson's disease. These are characteristic histological features of alcoholic liver disease, not Wilson's disease.
**Option C:** **Siderotic nodules** are indeed seen in Wilson's disease, as a result of **hemosiderin deposition** due to the breakdown of red blood cells.
**Option D:** **Fatty change** is indeed seen in Wilson's disease, as a result of the toxic effects of excess copper on the liver cells.
**Clinical Pearl / High-Yield Fact**
Wilson's disease is an autosomal recessive disorder caused by mutations in the ATP7B gene, which codes for a copper-transporting ATPase. The gene is responsible for the transport of copper out of the liver and into the bile.
**Correct Answer:** B. Mallory-Denk bodies are actually seen in alcoholic liver disease, not Wilson's disease.