**Core Concept**
Eosinophils play a crucial role in the pathophysiology of atopic asthma. These granulocytes are involved in the inflammatory response, particularly in the late phase of an allergic reaction. They contribute to the airway inflammation and hyperresponsiveness characteristic of asthma.

**Why the Correct Answer is Right**
In atopic asthma, the eosinophil count typically increases in response to allergen exposure. This is due to the release of cytokines, such as IL-5, which promote eosinophil proliferation and activation. Activated eosinophils release granules that contain major basic protein, eosinophil peroxidase, and eosinophil-derived neurotoxin, which contribute to airway damage and inflammation. The increased eosinophil count in the blood of patients with atopic asthma is a reflection of the ongoing inflammatory process in the airways.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not directly related to the pathophysiology of atopic asthma. While patients with asthma may experience anxiety or depression, this is not a characteristic change in their blood.
* **Option B:** Neutrophil counts may be elevated in certain types of asthma, such as severe exacerbations or in patients with chronic obstructive pulmonary disease (COPD). However, in atopic asthma, eosinophils are typically the predominant inflammatory cell.
* **Option C:** Platelet counts may be elevated in response to inflammation or stress, but this is not a specific change associated with atopic asthma.
* **Option D:** This option is not directly related to the pathophysiology of atopic asthma. While patients with asthma may experience fatigue or muscle weakness, this is not a characteristic change in their blood.

**Clinical Pearl / High-Yield Fact**
Remember that eosinophil counts are often used as a biomarker for atopic asthma and can guide treatment decisions. High-dose inhaled corticosteroids can reduce eosinophil counts and improve symptoms in patients with atopic asthma.

**Correct Answer:** B. Elevated eosinophil count.