**Question:** Chaga's disease does not involve -

A. Liver
B. Kidney
C. Central Nervous System (CNS)
D. Skin

**Core Concept:** Chaga's disease is a mycosis caused by the fungus Inonotus obliquus, commonly known as the chicken of the woods mushroom. This infection primarily affects immunocompromised individuals and is characterized by systemic dissemination.

**Why the Correct Answer is Right:** Chaga's disease primarily affects immunocompromised individuals, typically those with HIV/AIDS, and disseminates throughout the body. It primarily affects internal organs like the lungs, liver, and spleen. While the liver and kidney can be involved to some extent, the correct answer focuses on the specific aspect of Chaga's disease not involving the Central Nervous System (CNS) and the skin.

**Why Each Wrong Option is Incorrect:**

A. Liver: Although liver involvement is common in Chaga's disease, it is not the primary focus of the question.
B. Kidney: Kidney involvement is less common but still occurs in Chaga's disease.
C. Skin: Chaga's disease primarily affects internal organs and does not primarily involve the skin.
D. Central Nervous System (CNS): Chaga's disease does not primarily affect the CNS, hence it is not a primary focus of the question.

**Clinical Pearl:** Chaga's disease is a remarkable example of a fungal infection affecting immunocompromised individuals. The correct answer, CNS and skin involvement, highlights the importance of recognizing the primary focus of the question and understanding the typical pattern of fungal infections affecting immunocompromised hosts.

**Correct Answer:** Central Nervous System (CNS) and Skin