True regarding cervical cancer vaccine is/are -a) Bivalent and quadrivalent b) Given to married women in 20-45 years age groupc) MC subtypes 16, 18d) Two doses givene) Gives 100% protection

**Core Concept**
The human papillomavirus (HPV) vaccine is a preventive measure against cervical cancer, which is primarily caused by high-risk HPV types. The vaccine is designed to stimulate the immune system to recognize and target these oncogenic viruses.

**Why the Correct Answer is Right**
The correct answer involves understanding the types of HPV vaccines available and their composition. The quadrivalent vaccine protects against HPV types 6, 11, 16, and 18, while the bivalent vaccine targets types 16 and 18. These high-risk HPV types are responsible for the majority of cervical cancer cases. The vaccine is recommended for young women before they become sexually active, typically between 9 and 26 years of age. The recommended schedule for vaccination involves three doses, not two.

**Why Each Wrong Option is Incorrect**
**Option A:** Both bivalent and quadrivalent vaccines are available, but the statement "Given to married women in 20-45 years age group" is incorrect, as the vaccine is typically recommended for pre-adolescent girls and young women before they become sexually active.

**Option B:** The statement "Given to married women in 20-45 years age group" is incorrect, as the vaccine is not targeted towards married women in this age group.

**Option C:** The statement "MC subtypes 16, 18" is partially correct, as HPV types 16 and 18 are the most common high-risk types, but it does not specify that the quadrivalent vaccine also protects against HPV types 6 and 11.

**Option D:** The statement "Two doses given" is incorrect, as the recommended schedule for vaccination involves three doses.

**Option E:** The statement "Gives 100% protection" is incorrect, as no vaccine provides 100% protection against all strains of a virus.

**Clinical Pearl / High-Yield Fact**
It is essential to note that the HPV vaccine is most effective when administered before exposure to HPV, making it a crucial preventive measure for young women. The vaccine is not a substitute for regular cervical cancer screening, such as Pap smears and HPV testing.

**Correct Answer: C. MC subtypes 16, 18**