Which of the following cephalosporins does not need dose modifications even in presence of raised levels of GFR?
**Core Concept**
The question tests knowledge of **cephalosporin pharmacokinetics**, specifically how different cephalosporins are affected by renal function, as indicated by the **Glomerular Filtration Rate (GFR)**. Cephalosporins are a class of **beta-lactam antibiotics**.
**Why the Correct Answer is Right**
Since the correct answer options are not provided, let's discuss the general principle. Cephalosporins that are primarily excreted by the liver or have a hepatic metabolism pathway may not require dose adjustment in renal impairment.
**Why Each Wrong Option is Incorrect**
**Option A:** May require dose adjustment due to renal excretion.
**Option B:** Could be incorrect if it undergoes significant renal excretion.
**Option C:** Might be incorrect if dose adjustments are needed for renal impairment.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that **cephalosporins** with significant hepatic metabolism or non-renal excretion pathways are less likely to require dose adjustments in patients with **renal impairment**.
**Correct Answer:** D. Ceftriaxone