Cells charcteristic of Hodgkin&;s disease are –
**Core Concept**
Hodgkin's disease, also known as Hodgkin lymphoma, is a type of lymphoma characterized by the presence of distinctive cells known as Reed-Sternberg cells. These cells are a hallmark of the disease and play a crucial role in its diagnosis and pathophysiology.
**Why the Correct Answer is Right**
Reed-Sternberg cells are large, abnormal lymphocytes that are typically binucleated, with prominent nucleoli. They are thought to arise from germinal center B cells and are characterized by their expression of CD30 and CD15 antigens. The presence of Reed-Sternberg cells is a key diagnostic feature of Hodgkin lymphoma, and their identification is essential for distinguishing this disease from other types of lymphoma.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify the characteristic cells of Hodgkin's disease. While lymphocytes are a type of cell found in the lymphatic system, they are not unique to Hodgkin's disease.
**Option B:** This option is incorrect because it does not accurately describe the cells characteristic of Hodgkin's disease. While Reed-Sternberg cells are large and abnormal, they are not simply "large lymphocytes."
**Option C:** This option is incorrect because it is too vague and does not specify the distinctive cells of Hodgkin's disease.
**Clinical Pearl / High-Yield Fact**
Reed-Sternberg cells are typically binucleated and have prominent nucleoli, which can be a helpful diagnostic feature in distinguishing Hodgkin lymphoma from other types of lymphoma.
**Correct Answer: C. Reed-Sternberg cells.**