This drug depolarizer cell membranes of aerobic Gram Positive Bacteria. It is effective against vancomycin resistance entercoccal infection. It may cause myopathy especially in patients taking stating .it is
**Core Concept**
The question is testing the student's knowledge of a specific antibiotic that targets aerobic Gram-positive bacteria, particularly those resistant to vancomycin, such as vancomycin-resistant enterococci (VRE). The antibiotic in question is a depolarizer of cell membranes, leading to bacterial death.
**Why the Correct Answer is Right**
The correct answer is a drug that works by inhibiting cell wall synthesis, specifically targeting the enzyme transpeptidase. This leads to an imbalance of ionic gradients across the cell membrane, causing depolarization and ultimately, bacterial cell death. The drug is particularly effective against VRE, which has developed resistance to vancomycin. Additionally, this antibiotic is known to cause myopathy, especially when co-administered with statins, which can increase the risk of muscle damage.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the antibiotic's mechanism of action or its effectiveness against VRE.
**Option B:** This option is incorrect because it does not mention the drug's effect on cell membrane depolarization or its interaction with statins.
**Option C:** This option is incorrect because it does not accurately describe the antibiotic's mechanism of action or its effectiveness against VRE.
**Clinical Pearl / High-Yield Fact**
When treating patients with antibiotics that can cause myopathy, such as this drug, it is essential to monitor muscle enzymes and adjust the treatment plan accordingly. Additionally, patients taking statins should be closely monitored for signs of muscle damage.
**Correct Answer: C. Daptomycin**