Celiac disease is children is most commonly associated with:
Correct Answer: HLA-DQ2
Description: Ans. A. HLA-DQ2* Celiac disease is an immune-mediated enteropathy that is triggered by ingestion of gluten in genetically susceptible individuals.* Three factors can activate the disease; Ingestion of gluten-containing products; Dysfunction of intestinal mucosal barrier; and Genetic predisposition (HLA DQ2 / DQ8).* About 95% of patients of celiac disease express HLA-DQ2, and the remaining patients are usually HLA-DQ8 positive.
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Pediatrics
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