In Caveola, the Caveolin molecule is attached to inner layer of plasma membrane by –
**Core Concept**
Caveolae are small, flask-shaped invaginations of the plasma membrane, involved in various cellular processes such as cholesterol transport, signaling, and mechanotransduction. Caveolin is the primary protein component of caveolae, and its attachment to the plasma membrane is crucial for caveolae formation and function.
**Why the Correct Answer is Right**
Caveolin molecules are attached to the inner leaflet of the plasma membrane via their palmitoylated domains, which interact with the lipid bilayer. This attachment is essential for caveolin oligomerization and the subsequent formation of caveolae. The palmitoylation of caveolin allows it to anchor to the membrane, creating a platform for the assembly of caveolae.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify the correct location or mechanism of caveolin attachment to the plasma membrane.
**Option B:** This option is incorrect because it is too vague and does not accurately describe the specific interaction between caveolin and the plasma membrane.
**Clinical Pearl / High-Yield Fact**
Caveolae are involved in the regulation of various cellular processes, including cholesterol transport and signaling pathways. Understanding the structure and function of caveolae is essential for appreciating the role of caveolin in various diseases, such as atherosclerosis and cancer.
**Correct Answer: C.**