Causes of severe hypokalemic metabolic alkalosis with severe hypeension include

Correct Answer: Liddle syndrome
Description: Liddle syndrome - AD, gain-in-function mutations of ENaC subunits. Activating kidneys to excrete potassium retaining excessive sodium & water, leading to hypeension. C/F- severe hypeension with hypokalemia, unresponsive to spironolactone yet sensitive to amiloride
Category: Medicine
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