Causes of female pseudohermaphroditism –
Correct Answer: 21–alpha hydroxylase deficiency
Description: Ambiguous genitalia (Hermaphroditism)
Ambiguous genitalia is defined as a discrepancy between the external genitals and internal gonads.
They can be categorized : -
Female pseudohermaphroditism
Male pseudohermaphroditism
True hermaphroditism
Female pseudohermaphroditism.
Genotype is XX
Gonads are ovaries
External genitalia is virilized (male differentiation).
As there is no Mullarian inhibiting factor, Mullerian duct develops into uterus tubes and ovary. But due to the presence of androgen external genitalia are virilized.
Causes are:
Maternal virilizing tumour → Arrhenoblastoma
21 hydroxylase deficiency
11 beta hydroxylase deficiency
Maternal medications with androgen
Category:
Pediatrics
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