Causes of corneal neovascularisation
**Core Concept**
Corneal neovascularisation is the process of new blood vessel growth into the cornea, which can lead to vision loss and corneal opacity. This occurs due to an imbalance between angiogenic and anti-angiogenic factors in the cornea.
**Why the Correct Answer is Right**
Corneal neovascularisation is often caused by hypoxia, inflammation, or infection, which disrupts the normal functioning of the corneal endothelium and triggers the release of vascular endothelial growth factor (VEGF). VEGF is a potent angiogenic factor that stimulates the growth of new blood vessels. In the cornea, the breakdown of the blood-ocular barrier and the release of pro-inflammatory cytokines also contribute to the development of neovascularisation.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because while dry eye syndrome can cause corneal damage, it is not a direct cause of neovascularisation.
**Option B:** This option is incorrect because while contact lens wear can cause corneal irritation, it is not a primary cause of neovascularisation.
**Option C:** This option is incorrect because while certain medications can cause corneal toxicity, they are not a common cause of neovascularisation.
**Clinical Pearl / High-Yield Fact**
A key clinical correlation is that corneal neovascularisation is often seen in conditions such as keratoconus, Fuchs' endothelial dystrophy, and Mooren's ulcer. These conditions are characterized by corneal thinning, inflammation, and endothelial dysfunction, which can lead to the release of angiogenic factors.
**Correct Answer: C. Corneal injury, infection, or inflammation.**